2-Chlorotrityl chloride resin (200-400 mesh)
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| Longterm storage temperature: |
-20 ± 5 °C |
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| Substitution: |
1.0-2.5 mmol/g |
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A very acid sensitive resin suitable for the synthesis of protected peptide fragments by the Fmoc-strategy. In particular suitable for the preparation of C-terminal prolyl and cysteinyl peptides (please see 2-Chlorotrityl Chloride Resin-Linked Amino Acids). Release from this resin is achieved by using 1-50 % TFA in CH2Cl2 containing 8 % triisopropylsilane, AcOH/CF3CH2OH/CH2Cl2, 0.5 % TFA or hexafluoroisopropanol/CH2Cl2. This resin has been used in cyclization reactions under Heck reaction conditions, the solid phase synthesis of β-peptides via the Arndt-Eistert homologation of Fmoc-protected amino acid diazoketones and in Mannich reactions of alkynes, secondary amines and aldehydes in the presence of a copper (I) salt affording the corresponding aminomethylalkynyl adducts.
2-Chlorotrityl resin is highly suitable for the synthesis of peptide alcohols, e.g., peptaibols, and peptide ω-aminoalkylamides.
Literature:
K.Barlos et al., Tetrahedron Lett., 30, 3943 (1989)
K.Barlos et al., Tetrahedron Lett., 30, 3947 (1989)
K.Barlos et al., Int. J. Peptide Protein Res., 37, 513 (1991)
K.Barlos et al., Liebigs Ann. Chem., 215 (1993)
R.Bollhagen et al., J. Chem. Soc. Chem. Commun., 1994, 2559 (1994)
Y.Fujiwara et al., Chem. Pharm. Bull., 42, 724 (1994)
H.Wenschuh et al., J. Org. Chem., 60, 405 (1995)
R.E.Marti et al., Tetrahedron Lett., 38, 6145 (1997)
W.J.Hoekstra et al., Tetrahedron Lett., 38, 2629 (1997)
J.J.McNally et al., Tetrahedron Lett., 39, 967 (1998)
B.B.Shankar et al., Tetrahedron Lett., 39, 2447 (1999)
M.Karavoltsos et al., J. Pept. Sci., 8, 615 (2002)
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规格 |
包装 |
牌号 |
售价 |
保存条件 |
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BR |
100克 |
Yeexin |
4000 |
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